The patients were instructed to keep the product in contact with the oral mucosa for 2-3 minutes, and then swallow it. If there was no improvement in 4 weeks, the dose was then doubled to 5 ml, 2 times a day.

Clinical and subjective improvement (subjective and objective reduction or disappearance of pain, edema and inflammation, improvement in joint mobility and better tolerance to physical activity) was documented after 2 to 6 weeks of treatment in 10 out of 12 rheumatoid arthritis patients.

Ten additional osteoarthritis patients, average age of 58.4 years, with disease duration of 6 months to 11 years (average 5.6 years), and who were all on non-steroidal anti-inflammatory medicines, entered the trial. Nine out of the 10 patients reported a significant reduction of pain, and showed clinical reduction of inflammation between 15 and 21 days after starting the therapy.

Colostrum-derived products contain one or more immuno modulating agents that promote anti-inflammatory cytokine-type activity resembling the anti-inflammatory activity of cytokines 4, 10, 13, 15 and 16. The Infopeptides appear to act nonspecifically, allowing the organism to regain normal functioning patterns.

This medication is given orally, and is low cost compared to other biological response modifiers. It's most profound effect is on pain relief.

"The Clinical Use of Bovine Colostrum," Nitsch A and Nitsch FP, Journal of Orthomolecular Medicine, 1998;13(2):110-118. (Address: Alejandro Nitsch, MD, 15-45 zone 10. Centro Empresarial Tower 1 Office No. 405, Guatemala City, Guatemala 01010) 30275.